r-bioc-qvalue-1.34.0/0000755000175000017510000000000012140704145014124 5ustar moellermoellerr-bioc-qvalue-1.34.0/DESCRIPTION0000755000175000017510000000221512127220315015632 0ustar moellermoellerPackage: qvalue Title: Q-value estimation for false discovery rate control Version: 1.34.0 Author: Alan Dabney and John D. Storey , with assistance from Gregory R. Warnes Description: This package takes a list of p-values resulting from the simultaneous testing of many hypotheses and estimates their q-values. The q-value of a test measures the proportion of false positives incurred (called the false discovery rate) when that particular test is called significant. Various plots are automatically generated, allowing one to make sensible significance cut-offs. Several mathematical results have recently been shown on the conservative accuracy of the estimated q-values from this software. The software can be applied to problems in genomics, brain imaging, astrophysics, and data mining. Maintainer: John D. Storey Imports: graphics, grDevices, stats, tcltk License: LGPL biocViews: MultipleComparisons Packaged: 2013-04-04 06:42:21 UTC; biocbuild r-bioc-qvalue-1.34.0/NAMESPACE0000644000175000017510000000104012127130117015333 0ustar moellermoellerimportFrom(graphics, hist, lines, mtext, par, plot) importFrom(grDevices, dev.off, pdf) importFrom(stats, predict, quantile, smooth.spline) importFrom(tcltk, tclvalue, "tclvalue<-", tclVar, tkbutton, tkcheckbutton, tkconfigure, tkdestroy, tkentry, tkframe, tkgetOpenFile, tkgetSaveFile, tkgrid, tkinsert, tklabel, tkpack, tkradiobutton, tkscrollbar, tkset, tktext, tktoplevel, tkwm.focusmodel, tkwm.title, tkyview) export(plot.qvalue, qplot, qsummary, qvalue, qvalue.gui, qwrite, summary.qvalue) r-bioc-qvalue-1.34.0/R/0000755000175000017510000000000012127130115014320 5ustar moellermoellerr-bioc-qvalue-1.34.0/R/qvalue.R0000755000175000017510000007215112127130115015751 0ustar moellermoellerqvalue <- function(p=NULL, lambda=seq(0,0.90,0.05), pi0.method="smoother", fdr.level=NULL, robust=FALSE, gui=FALSE, smooth.df = 3, smooth.log.pi0 = FALSE) { #Input #============================================================================= #p: a vector of p-values (only necessary input) #fdr.level: a level at which to control the FDR (optional) #lambda: the value of the tuning parameter to estimate pi0 (optional) #pi0.method: either "smoother" or "bootstrap"; the method for automatically # choosing tuning parameter in the estimation of pi0, the proportion # of true null hypotheses #robust: an indicator of whether it is desired to make the estimate more robust # for small p-values and a direct finite sample estimate of pFDR (optional) #gui: A flag to indicate to 'qvalue' that it should communicate with the gui. ## change by Alan # Should not be specified on command line. #smooth.df: degrees of freedom to use in smoother (optional) #smooth.log.pi0: should smoothing be done on log scale? (optional) # #Output #============================================================================= #call: gives the function call #pi0: an estimate of the proportion of null p-values #qvalues: a vector of the estimated q-values (the main quantity of interest) #pvalues: a vector of the original p-values #significant: if fdr.level is specified, an indicator of whether the q-value # fell below fdr.level (taking all such q-values to be significant controls # FDR at level fdr.level) #Set up communication with GUI, if appropriate # print(sys.calls()) # print(sys.frames()) # if(gui) { # idx <- (1:sys.nframe())[as.character(sys.calls()) == "qvalue.gui()"] # gui.env <- sys.frames()[[idx]] # } #This is just some pre-processing if(is.null(p)) ## change by Alan {qvalue.gui(); return("Launching point-and-click...")} if(gui & !interactive()) ## change by Alan gui = FALSE if(min(p)<0 || max(p)>1) { if(gui) ## change by Alan: check for GUI eval(expression(postMsg(paste("ERROR: p-values not in valid range.", "\n"))), parent.frame()) else print("ERROR: p-values not in valid range.") return(0) } if(length(lambda)>1 && length(lambda)<4) { if(gui) eval(expression(postMsg(paste("ERROR: If length of lambda greater than 1, you need at least 4 values.", "\n"))), parent.frame()) else print("ERROR: If length of lambda greater than 1, you need at least 4 values.") return(0) } if(length(lambda)>1 && (min(lambda) < 0 || max(lambda) >= 1)) { ## change by Alan: check for valid range for lambda if(gui) eval(expression(postMsg(paste("ERROR: Lambda must be within [0, 1).", "\n"))), parent.frame()) else print("ERROR: Lambda must be within [0, 1).") return(0) } m <- length(p) #These next few functions are the various ways to estimate pi0 if(length(lambda)==1) { if(lambda<0 || lambda>=1) { ## change by Alan: check for valid range for lambda if(gui) eval(expression(postMsg(paste("ERROR: Lambda must be within [0, 1).", "\n"))), parent.frame()) else print("ERROR: Lambda must be within [0, 1).") return(0) } pi0 <- mean(p >= lambda)/(1-lambda) pi0 <- min(pi0,1) } else { pi0 <- rep(0,length(lambda)) for(i in 1:length(lambda)) { pi0[i] <- mean(p >= lambda[i])/(1-lambda[i]) } if(pi0.method=="smoother") { if(smooth.log.pi0) pi0 <- log(pi0) spi0 <- smooth.spline(lambda,pi0,df=smooth.df) pi0 <- predict(spi0,x=max(lambda))$y if(smooth.log.pi0) pi0 <- exp(pi0) pi0 <- min(pi0,1) } else if(pi0.method=="bootstrap") { minpi0 <- min(pi0) mse <- rep(0,length(lambda)) pi0.boot <- rep(0,length(lambda)) for(i in 1:100) { p.boot <- sample(p,size=m,replace=TRUE) for(i in 1:length(lambda)) { pi0.boot[i] <- mean(p.boot>lambda[i])/(1-lambda[i]) } mse <- mse + (pi0.boot-minpi0)^2 } pi0 <- min(pi0[mse==min(mse)]) pi0 <- min(pi0,1) } else { ## change by Alan: check for valid choice of 'pi0.method' (only necessary on command line) print("ERROR: 'pi0.method' must be one of 'smoother' or 'bootstrap'.") return(0) } } if(pi0 <= 0) { if(gui) eval(expression(postMsg( paste("ERROR: The estimated pi0 <= 0. Check that you have valid p-values or use another lambda method.", "\n"))), parent.frame()) else print("ERROR: The estimated pi0 <= 0. Check that you have valid p-values or use another lambda method.") return(0) } if(!is.null(fdr.level) && (fdr.level<=0 || fdr.level>1)) { ## change by Alan: check for valid fdr.level if(gui) eval(expression(postMsg(paste("ERROR: 'fdr.level' must be within (0, 1].", "\n"))), parent.frame()) else print("ERROR: 'fdr.level' must be within (0, 1].") return(0) } #The estimated q-values calculated here u <- order(p) # change by Alan # ranking function which returns number of observations less than or equal qvalue.rank <- function(x) { idx <- sort.list(x) fc <- factor(x) nl <- length(levels(fc)) bin <- as.integer(fc) tbl <- tabulate(bin) cs <- cumsum(tbl) tbl <- rep(cs, tbl) tbl[idx] <- tbl return(tbl) } v <- qvalue.rank(p) qvalue <- pi0*m*p/v if(robust) { qvalue <- pi0*m*p/(v*(1-(1-p)^m)) } qvalue[u[m]] <- min(qvalue[u[m]],1) for(i in (m-1):1) { qvalue[u[i]] <- min(qvalue[u[i]],qvalue[u[i+1]],1) } #The results are returned if(!is.null(fdr.level)) { retval <- list(call=match.call(), pi0=pi0, qvalues=qvalue, pvalues=p, fdr.level=fdr.level, ## change by Alan significant=(qvalue <= fdr.level), lambda=lambda) } else { retval <- list(call=match.call(), pi0=pi0, qvalues=qvalue, pvalues=p, lambda=lambda) } class(retval) <- "qvalue" return(retval) } qplot <- function(qobj, rng=c(0.0, 0.1), smooth.df = 3, smooth.log.pi0 = FALSE, ...) { ## change by Alan: ## 'rng' a vector instead of an upper bound alone #Input #============================================================================= #qobj: a q-value object returned by the qvalue function #rng: the range of q-values to be plotted (optional) #smooth.df: degrees of freedom to use in smoother (optional) #smooth.log.pi0: should smoothing be done on log scale? (optional) # #Output #============================================================================= #Four plots: #Upper-left: pi0.hat(lambda) versus lambda with a smoother #Upper-right: q-values versus p-values #Lower-left: number of significant tests per each q-value cut-off #Lower-right: number of expected false positives versus number of significant tests q2 <- qobj$qval[order(qobj$pval)] if(min(q2) > rng[2]) {rng <- c(min(q2), quantile(q2, 0.1))} ## change by Alan: replace 'rng' with vector p2 <- qobj$pval[order(qobj$pval)] par(mfrow=c(2,2)) lambda <- qobj$lambda if(length(lambda)==1) {lambda <- seq(0,max(0.90,lambda),0.05)} pi0 <- rep(0,length(lambda)) for(i in 1:length(lambda)) { pi0[i] <- mean(p2>lambda[i])/(1-lambda[i]) } if(smooth.log.pi0) pi0 <- log(pi0) spi0 <- smooth.spline(lambda,pi0,df=smooth.df) if(smooth.log.pi0) { pi0 <- exp(pi0) spi0$y <- exp(spi0$y) } pi00 <- round(qobj$pi0,3) plot(lambda,pi0,xlab=expression(lambda),ylab=expression(hat(pi)[0](lambda)),pch=".") mtext(substitute(hat(pi)[0] == that, list(that= pi00))) lines(spi0) plot(p2[q2 >= rng[1] & q2 <= rng[2]], q2[q2 >= rng[1] & q2 <= rng[2]], type = "l", xlab = "p-value", ## changes by Alan ylab = "q-value") plot(q2[q2 >= rng[1] & q2 <= rng[2]], (1 + sum(q2 < rng[1])):sum(q2 <= rng[2]), type="l", xlab="q-value cut-off", ylab="significant tests") plot((1 + sum(q2 < rng[1])):sum(q2 <= rng[2]), q2[q2 >= rng[1] & q2 <= rng[2]] * (1 + sum(q2 < rng[1])):sum(q2 <= rng[2]), type = "l", xlab = "significant tests", ylab = "expected false positives") par(mfrow=c(1,1)) } plot.qvalue <- function(x, ...) qplot(x, ...) qwrite <- function(qobj, filename="my-qvalue-results.txt") { #Input #============================================================================= #qobj: a q-value object returned by the qvalue function #filename: the name of the file where the results are written # #Output #============================================================================= #A file sent to "filename" with the following: #First row: the estimate of the proportion of true negatives, pi0 #Second row: FDR significance level (if specified) ## change by Alan #Third row and below: the p-values (1st column), the estimated q-values (2nd column), # and indicator of significance level if appropriate (3rd column) cat(c("pi0:", qobj$pi0, "\n\n"), file=filename, append=FALSE) if(any(names(qobj) == "fdr.level")) { cat(c("FDR level:", qobj$fdr.level, "\n\n"), file=filename, append=TRUE) cat(c("p-value q-value significant", "\n"), file=filename, append=TRUE) ## change by Alan (space-delimited now) # for(i in 1:length(qobj$qval)) { # cat(c(qobj$pval[i], "\t", qobj$qval[i], "\t", qobj$significant[i], "\n"), file=filename, append=TRUE) # } write(t(cbind(qobj$pval, qobj$qval, qobj$significant)), file=filename, ncolumns=3, append=TRUE) ## change by Alan } else { cat(c("p-value q-value", "\n"), file=filename, append=TRUE) # for(i in 1:length(qobj$qval)) { # cat(c(qobj$pval[i], "\t", qobj$qval[i], "\n"), file=filename, append=TRUE) # } write(t(cbind(qobj$pval, qobj$qval)), file=filename, ncolumns=2, append=TRUE) } } qsummary <- function (qobj, cuts=c(0.0001, 0.001, 0.01, 0.025, 0.05, 0.10, 1), digits=getOption("digits"), ...) { cat("\nCall:\n", deparse(qobj$call), "\n\n", sep = "") cat("pi0:",format(qobj$pi0, digits=digits),"\n", sep="\t") cat("\n") cat("Cumulative number of significant calls:\n") cat("\n") counts <- sapply(cuts, function(x) c("p-value"=sum(qobj$pvalues < x), "q-value"=sum(qobj$qvalues < x))) colnames(counts) <- paste("<", cuts, sep="") print(counts) cat("\n") invisible(qobj) } summary.qvalue <- function(object, ...) { qsummary(object, ...) } #################################################### ## TCL-TK GUI for John Storey's Q-Value Software. ## ## Alan Dabney, 10/01/03 ## #################################################### qvalue.gui <- function(dummy = NULL) { if(interactive()) { out <- NULL inFileName.var <- tclVar("") pp <- NULL from.var.1 = tclVar("0.0") to.var.1 = tclVar("0.90") by.var.1 = tclVar("0.05") from.var.2 = tclVar("0.0") to.var.2 = tclVar("0.1") single.var = tclVar("") lambda.var = tclVar(1) pi0.var = tclVar(1) df.var = tclVar("3") log.no.var = tclVar(1) robust.var = tclVar(0) levelSpec.var = tclVar(0) level.var = tclVar("0.05") plotChoice.var = tclVar(1) titleFont <- "Helvetica 14" normalFont <- "Helvetica 10" ######################## ## Utility functions ## ######################## findPVals <- function() { tclvalue(inFileName.var) <- tclvalue(tkgetOpenFile()) } readPVals <- function() { flnm <- tclvalue(inFileName.var) if(flnm == "") { postMsg("ERROR: No file selected.\n") } else { postMsg("Reading p-values...") pvals = scan(flnm) if(is.null(pvals) == FALSE) { assign("pp", pvals, inherits = TRUE) postMsg("done.\n") } } } lambda.fnc <- function() { if(tclvalue(lambda.var) == 1) { tkconfigure(from.ety.1, state = "normal") tkconfigure(to.ety.1, state = "normal") tkconfigure(by.ety.1, state = "normal") tkconfigure(single.ety, state = "disabled") } else { tkconfigure(from.ety.1, state = "disabled") tkconfigure(to.ety.1, state = "disabled") tkconfigure(by.ety.1, state = "disabled") tkconfigure(single.ety, state = "normal") } } smoother.fnc <- function() { if(tclvalue(pi0.var) == 1) tkconfigure(smoothOptions.btn, state = "normal") else tkconfigure(smoothOptions.btn, state = "disabled") } smoothOptions.fnc <- function() { base <- tktoplevel() tkwm.title(base, "Smoother") df.var.0 <- tclvalue(df.var) log.no.var.0 <- tclvalue(log.no.var) smooth.ok.fnc <- function() { tkdestroy(base) } smooth.cancel.fnc <- function() { tclvalue(df.var) <- df.var.0 tclvalue(log.no.var) <- log.no.var.0 tkdestroy(base) } top.frm <- tkframe(base, borderwidth = 2) inset.frm <- tkframe(top.frm, relief = "raised", bd = 2) df.frm <- tkframe(inset.frm) df.lbl <- tklabel(df.frm, text = "Degrees of freedom:", font = normalFont) df.ety <- tkentry(df.frm, textvariable = df.var, font = normalFont, width = 3, justify = "center") tkpack(df.lbl, side = "left") tkpack(df.ety, side = "left") log.lbl.frm <- tkframe(inset.frm) log.lbl <- tklabel(log.lbl.frm, text = "Variable to smooth:", font = normalFont) tkpack(log.lbl, side = "left") log.no.frm <- tkframe(inset.frm) log.no.cbtn <- tkradiobutton(log.no.frm, text = "pi0", font = normalFont, variable = log.no.var, value = 1) tkpack(log.no.cbtn, side = "left") log.yes.frm <- tkframe(inset.frm) log.yes.cbtn <- tkradiobutton(log.yes.frm, text = "log pi0", font = normalFont, variable = log.no.var, value = 0) tkpack(log.yes.cbtn, side = "left") btn.frm <- tkframe(inset.frm) ok.btn <- tkbutton(btn.frm, text = "OK", font = normalFont, command = smooth.ok.fnc) cancel.btn <- tkbutton(btn.frm, text = "Cancel", font = normalFont, command = smooth.cancel.fnc) tkgrid(ok.btn, cancel.btn) tkpack(df.frm, padx = 5, anchor = "w", fill = "x", expand = TRUE) tkpack(log.lbl.frm, padx = 5, anchor = "w", fill = "x", expand = TRUE) tkpack(log.no.frm, padx = 10, anchor = "w", fill = "x", expand = TRUE) tkpack(log.yes.frm, padx = 10, anchor = "w", fill = "x", expand = TRUE) tkpack(btn.frm, anchor = "e") tkpack(inset.frm) tkpack(top.frm) } level.fnc <- function() { if(tclvalue(levelSpec.var) == 1) tkconfigure(level.ety, state = "normal") else tkconfigure(level.ety, state = "disabled") } execute.fnc <- function() { if(is.null(pp)) postMsg("ERROR: P-values haven't been read yet.\n") else { postMsg("Computing q-values...") if(tclvalue(lambda.var) == 1) lambda <- seq(from = as.numeric(tclvalue(from.var.1)), to = as.numeric(tclvalue(to.var.1)), by = as.numeric(tclvalue(by.var.1))) else { lambda <- as.numeric(tclvalue(single.var)) if(is.na(lambda)) { postMsg("ERROR: Please specify value for lambda.\n") return() } # else if(lambda <= 0.0 || lambda >= 1.0) { # postMsg("ERROR: Lambda must be between 0.0 and 1.0.\n") # return() # } } if(tclvalue(pi0.var) == 1) pi0.method <- "smoother" else pi0.method <- "bootstrap" if(tclvalue(levelSpec.var) == 1) { fdr.level <- as.numeric(tclvalue(level.var)) if(is.na(fdr.level)) { postMsg("ERROR: Please specify FDR level.\n") return() } # else if(fdr.level <= 0.0 || fdr.level >= 1.0) { # postMsg("aborted.\n") # postMsg("FDR level must be between 0.0 and 1.0.\n") # return() # } } else fdr.level <- NULL if(tclvalue(robust.var) == 1) robust <- TRUE else robust <- FALSE if(tclvalue(log.no.var) == 1) smooth.log.pi0 = TRUE else smooth.log.pi0 = FALSE qout = qvalue(p = pp, lambda = lambda, pi0.method = pi0.method, fdr.level = fdr.level, robust = robust, gui = TRUE, smooth.df = as.numeric(tclvalue(df.var)), smooth.log.pi0 = smooth.log.pi0) if(class(qout) == "qvalue") { tclvalue(to.var.2) = as.character(round(qout$pi0, 4)) assign("out", qout, inherits = TRUE) postMsg(paste("done: pi_0 = ", round(qout$pi0, 4), ".\n", sep = "")) } } } plotChoice.fnc <- function() { if(tclvalue(plotChoice.var) == 1 | tclvalue(plotChoice.var) == 2) { tkconfigure(from.ety.2, state = "disabled") tkconfigure(to.ety.2, state = "disabled") } else { tkconfigure(from.ety.2, state = "normal") tkconfigure(to.ety.2, state = "normal") } } histPVals <- function() { if(is.null(pp)) postMsg("ERROR: P-values haven't been read yet.\n") else { par(mfrow = c(1, 1)) hist(pp, main = "Histogram of P-Values") } } plot.fnc <- function() { if(tclvalue(plotChoice.var) == 1) { if(is.null(pp)) postMsg("ERROR: P-values haven't been read yet.\n") else { par(mfrow = c(1, 1)) hist(pp, main = "Histogram of P-Values", xlab = "") } } else if(tclvalue(plotChoice.var) == 2) { if(is.null(out)) postMsg("ERROR: Q-values haven't been computed yet.\n") else if(class(out) == "qvalue") { par(mfrow = c(1, 1)) hist(out$qvalues, main = "Histogram of Q-Values", xlab = "") } } else { if(tclvalue(log.no.var) == 1) smooth.log.pi0 = TRUE else smooth.log.pi0 = FALSE if(is.null(out)) postMsg("ERROR: Q-values haven't been computed yet.\n") else if(class(out) == "qvalue") qplot(out, rng = as.numeric(c(tclvalue(from.var.2), tclvalue(to.var.2))), smooth.df = as.numeric(tclvalue(df.var)), smooth.log.pi0 = smooth.log.pi0) } } saveOutput.fnc <- function() { if(is.null(out)) postMsg("ERROR: Q-values haven't been computed yet.\n") else if(class(out) == "qvalue") { postMsg("Writing results to file...") flnm <- tclvalue(tkgetSaveFile()) if(flnm != "") { qwrite(out, filename = flnm) postMsg("done.\n") } else postMsg("aborted.\n") } } savePlot.fnc <- function() { if(tclvalue(plotChoice.var) == 1) { if(is.null(pp)) postMsg("ERROR: P-values haven't been read yet.\n") else { flnm <- tclvalue(tkgetSaveFile(defaultextension = "pdf", filetypes = "{{PDF File} {.pdf}}")) if(flnm != "") { pdf(flnm) par(mfrow = c(1, 1)) hist(pp, main = "Histogram of P-Values", xlab = "") dev.off() postMsg("Plot saved.\n") } else postMsg("No file selected. Plot not saved.\n") } } else if(tclvalue(plotChoice.var) == 2) { if(is.null(out)) postMsg("ERROR: Q-values haven't been computed yet.\n") else if(class(out) == "qvalue") { flnm <- tclvalue(tkgetSaveFile(defaultextension = "pdf")) if(flnm != "") { pdf(flnm) par(mfrow = c(1, 1)) hist(out$qvalues, main = "Histogram of Q-Values", xlab = "") dev.off() postMsg("Plot saved.\n") } else postMsg("No file selected. Plot not saved.\n") } } else { if(is.null(out)) postMsg("ERROR: Q-values haven't been computed yet.\n") else if(class(out) == "qvalue") { flnm <- tclvalue(tkgetSaveFile(defaultextension = "pdf")) if(flnm != "") { pdf(flnm) qplot(out, rng = as.numeric(c(tclvalue(from.var.2), tclvalue(to.var.2)))) dev.off() postMsg("Plot saved.\n") } else postMsg("No file selected. Plot not saved.\n") } } } postMsg <- function(msg) { tkconfigure(message.txt, state = "normal") tkinsert(message.txt, "end", msg) tkconfigure(message.txt, state = "disabled") } errorHandler <- function() { postMsg(paste("An R error has occurred: ", geterrmessage(), sep = "")) } ## Reroute R errors to the message box options(error = errorHandler, show.error.messages = FALSE) ############## ## GUI code ## ############## ## Top level base <- tktoplevel() tkwm.title(base, "QVALUE") top.frm <- tkframe(base, borderwidth = 2) ## P-Value frame contains text field, browse button, load button, histogram button. pValue.frm <- tkframe(top.frm, relief = "raised", bd = 2) tkpack(tklabel(pValue.frm, text = "Read P-Values:", font = titleFont), anchor = "w") pValueInset.frm <- tkframe(pValue.frm, relief = "groove", bd = 2) inFileName.frm <- tkframe(pValueInset.frm) inFileName.lbl <- tklabel(inFileName.frm, text = "File Name:", font = normalFont) inFileName.ety <- tkentry(inFileName.frm, textvariable = inFileName.var, font = normalFont, justify = "center") tkpack(inFileName.lbl, side = "left") tkpack(inFileName.ety, side = "right", fill = "x", expand = TRUE) tkpack(inFileName.frm, fill = "x", expand = TRUE) pButtons.frm <- tkframe(pValueInset.frm) browse.btn <- tkbutton(pButtons.frm, text = "Browse", font = normalFont, command = findPVals) load.btn <- tkbutton(pButtons.frm, text = "Load", font = normalFont, command = readPVals) tkgrid(browse.btn, load.btn) tkpack(pButtons.frm, anchor = "e") tkpack(pValueInset.frm, fill = "x") ## Options frame allows user to specify lambda and pi_0 estimation method. options.frm <- tkframe(top.frm, relief = "raised", bd = 2) tkpack(tklabel(options.frm, text = "Optional Arguments:", font = titleFont), anchor = "w") optionsInset.frm <- tkframe(options.frm, relief = "groove", bd = 2) #### Specify lambda lambdaLabel.frm <- tkframe(optionsInset.frm) tkpack(tklabel(lambdaLabel.frm, text = "Specify lambda:", font = normalFont), anchor = "w") tkpack(lambdaLabel.frm, fill = "x", expand = TRUE) lambdaRange.frm <- tkframe(optionsInset.frm, padx = 10) range.rbtn <- tkradiobutton(lambdaRange.frm, text = "Range", font = normalFont, value = 1, variable = lambda.var, command = lambda.fnc) from.lbl.1 <- tklabel(lambdaRange.frm, text = "from:", font = normalFont) to.lbl.1 <- tklabel(lambdaRange.frm, text = "to:", font = normalFont) by.lbl.1 <- tklabel(lambdaRange.frm, text = "by:", font = normalFont) from.ety.1 <- tkentry(lambdaRange.frm, textvariable = from.var.1, font = normalFont, width = 5, justify = "center") to.ety.1 <- tkentry(lambdaRange.frm, textvariable = to.var.1, font = normalFont, width = 5, justify = "center") by.ety.1 <- tkentry(lambdaRange.frm, textvariable = by.var.1, font = normalFont, width = 5, justify = "center") tkpack(range.rbtn, side = "left", anchor = "w") tkpack(from.lbl.1, side = "left") tkpack(from.ety.1, side = "left") tkpack(to.lbl.1, side = "left") tkpack(to.ety.1, side = "left") tkpack(by.lbl.1, side = "left") tkpack(by.ety.1, side = "left") tkpack(lambdaRange.frm, fill = "x", expand = TRUE) lambdaSingle.frm <- tkframe(optionsInset.frm, padx = 10) single.rbtn <- tkradiobutton(lambdaSingle.frm, text = "Single No.:", font = normalFont, value = 0, variable = lambda.var, command = lambda.fnc) single.ety <- tkentry(lambdaSingle.frm, textvariable = single.var, font = normalFont, width = 5, state = "disabled", justify = "center") tkpack(single.rbtn, side = "left", anchor = "w") tkpack(single.ety, side = "left") tkpack(lambdaSingle.frm, fill = "x", expand = TRUE) #### Specify bootstrap or smoother method methodLabel.frm <- tkframe(optionsInset.frm) tkpack(tklabel(methodLabel.frm, text = "Choose pi_0 method:", font = normalFont), anchor = "w") tkpack(methodLabel.frm, fill = "x", expand = TRUE) methodSmooth.frm <- tkframe(optionsInset.frm, padx = 10) smoother.rbtn <- tkradiobutton(methodSmooth.frm, text = "Smoother", font = normalFont, value = 1, variable = pi0.var, command = smoother.fnc) smoothOptions.btn <- tkbutton(methodSmooth.frm, text = "Advanced Options", font = normalFont, command = smoothOptions.fnc) tkpack(smoother.rbtn, side = "left", anchor = "w") tkpack(smoothOptions.btn, side = "left") tkpack(methodSmooth.frm, fill = "x", expand = TRUE) methodBstrap.frm <- tkframe(optionsInset.frm, padx = 10) bootstrap.rbtn <- tkradiobutton(methodBstrap.frm, text = "Bootstrap", font = normalFont, value = 0, variable = pi0.var, command = smoother.fnc) tkpack(bootstrap.rbtn, side = "left", anchor = "w") tkpack(methodBstrap.frm, fill = "x", expand = TRUE) #### Specify robust method robust.frm <- tkframe(optionsInset.frm) robust.cbtn <- tkcheckbutton(robust.frm, text = "Use robust method", font = normalFont, variable = robust.var) tkpack(robust.cbtn, anchor = "w") tkpack(robust.frm, fill = "x", expand = TRUE) #### Specify FDR level level.frm <- tkframe(optionsInset.frm) level.cbtn <- tkcheckbutton(level.frm, text = "Specify FDR level:", font = normalFont, variable = levelSpec.var, command = level.fnc) level.ety <- tkentry(level.frm, textvariable = level.var, font = normalFont, width = 5, state = "disabled", justify = "center") tkpack(level.cbtn, side = "left", anchor = "w") tkpack(level.ety, side = "left") tkpack(level.frm, fill = "x", expand = TRUE) tkpack(optionsInset.frm, fill = "x", expand = TRUE) ## Action frame action.frm <- tkframe(top.frm, relief = "raised", bd = 2) tkpack(tklabel(action.frm, text = "Compute Q-Values:", font = titleFont), anchor = "w") actionInset.frm <- tkframe(action.frm, relief = "groove", bd = 2) execute.btn <- tkbutton(actionInset.frm, text = "Execute", font = normalFont, command = execute.fnc) saveOutput.btn <- tkbutton(actionInset.frm, text = "Save Output", font = normalFont, command = saveOutput.fnc) tkpack(saveOutput.btn, side = "right", anchor = "e") ## padx argument here spreads buttons out tkpack(execute.btn, side = "right") tkpack(actionInset.frm, fill = "x", expand = TRUE) ## Plot frame plot.frm <- tkframe(top.frm, relief = "raised", bd = 2) tkpack(tklabel(plot.frm, text = "Plots:", font = titleFont), anchor = "w") plotInset.frm <- tkframe(plot.frm, relief = "groove", bd = 2) pHist.frm <- tkframe(plotInset.frm, padx = 10) pHist.rbtn <- tkradiobutton(pHist.frm, text = "P-value histogram", font = normalFont, value = 1, variable = plotChoice.var, command = plotChoice.fnc) tkpack(pHist.rbtn, side = "left", anchor = "w") tkpack(pHist.frm, fill = "x", expand = TRUE) qHist.frm <- tkframe(plotInset.frm, padx = 10) qHist.rbtn <- tkradiobutton(qHist.frm, text = "Q-value histogram", font = normalFont, value = 2, variable = plotChoice.var, command = plotChoice.fnc) tkpack(qHist.rbtn, side = "left", anchor = "w") tkpack(qHist.frm, fill = "x", expand = TRUE) qPlots.frm <- tkframe(plotInset.frm, padx = 10) qPlots.rbtn <- tkradiobutton(qPlots.frm, text = "Q-plots,", font = normalFont, value = 3, variable = plotChoice.var, command = plotChoice.fnc) from.lbl.2 <- tklabel(qPlots.frm, text = "range from:", font = normalFont) to.lbl.2 <- tklabel(qPlots.frm, text = "to:", font = normalFont) from.ety.2 <- tkentry(qPlots.frm, textvariable = from.var.2, font = normalFont, width = 7, state = "disabled", justify = "center") to.ety.2 <- tkentry(qPlots.frm, textvariable = to.var.2, font = normalFont, width = 7, state = "disabled", justify = "center") tkpack(qPlots.rbtn, side = "left", anchor = "w") tkpack(from.lbl.2, side = "left") tkpack(from.ety.2, side = "left") tkpack(to.lbl.2, side = "left") tkpack(to.ety.2, side = "left") tkpack(qPlots.frm, fill = "x", expand = TRUE) plot.btn <- tkbutton(plotInset.frm, text = "Make Plot", font = normalFont, command = plot.fnc) savePlot.btn <- tkbutton(plotInset.frm, text = "Save Plot to PDF", font = normalFont, command = savePlot.fnc) tkpack(savePlot.btn, side = "right", anchor = "e") tkpack(plot.btn, side = "right") tkpack(plotInset.frm, fill = "x", expand = TRUE) ## Message box message.frm <- tkframe(top.frm, relief = "raised", bd = 2) message.txt <- tktext(message.frm, bg = "white", font = normalFont, height = 5, width = 5) message.scr <- tkscrollbar(message.frm, command = function(...) tkyview(message.txt, ...)) tkconfigure(message.txt, yscrollcommand = function(...) tkset(message.scr, ...)) tkpack(message.txt, side = "left", fill = "x", expand = TRUE) tkpack(message.scr, side = "right", fill = "y") tkpack(pValue.frm, fill = "x") tkpack(options.frm, fill = "x") tkpack(action.frm, fill = "x") tkpack(plot.frm, fill = "x") tkpack(message.frm, fill = "x") tkpack(top.frm) tkwm.focusmodel(base, "active") } } r-bioc-qvalue-1.34.0/data/0000755000175000017510000000000012127130116015031 5ustar moellermoellerr-bioc-qvalue-1.34.0/data/hedenfalk.RData0000755000175000017510000005561612127130116017707 0ustar moellermoellereǘ4ty.W%𵺛"Yic{@.xifhksmET^=kEu`vm^ewa0?QVmߑ쑝N:zq'^GUh߱w_(m9`z!V -:ݷ{L5}ZQ[oq x<4BᨅnVtLGL. ?%6ڷ) Ww cɺh^< L&O-;10h3#b轍1? h?dfaQŮuJ#_iMZuaGĝhF) أۗ-f93ΞaKQJ/d83gɿ.G- a4OstŦDК3޾d䶯[ߩ䣰u' :6{5#,1 )<н,Q52 IfĢ ~ 襻  U{6Qe{v8 B} %=եtm/7bbh|S1˨32H TܭpB8d[q;sv|Jˣ60o~.O[G,p0Қ-~J]%lf_=7T&^>yss["ukܭ])3 V]-c]; XKo7+@~07Bߺ˪`jBUmC\en=bzeWueLh[(@:mD7+=7v^GU}{XJPGT]Lhjz %hz6vLtY;V@s2s-'f9zD| ;C*"#.;siq;tYut>VGJr5Lc>=mz;-NjuXx|<3־c1"$l6*v5:o+zs>& 1dbЭ͍N.6u}_c%3Ogr=]tT@Jg_{/1 }th&0XPL҃NG0c/T7\qvg$1*p"&tم]Oa-UzYKbUhӐ-_=<~M:fwQ93=Ţm%~&) ,MHBp (GǓbru) ,f1u?ez4څ0@W`܊s.Sn1FG:vu}C|<;6:}>nU`a]MK( s~QN~ B&! 쥭EI7;2+0[=ϧ}R>b~;R@ÍV I2h>CC\wP}L[~T\ݹj#orh,M:żDc!FRN) vU ?P%'kj5h/5ʃ.ۗQq-CF.[ەuQON%#DNP n (F(_OhG_yRa"nc@Pt3l.ZWh?GOȎHU{B<ǝwALvn mpcHC/+a4O>M湌KRz#U ZS_xir-"&>_Dlϋ2GBKT_ )-4021̱:%ώ%cxD FajXͳTpiL| Y@-0PpY ۿx_rي'~MfoЯ6b†%|ϙjP̿c,>M4<9O\[ i6|nڥ큾du )K rX;~EE1d4$ot {%@٥ T=|,˺.4(8B^j N8a ν"]}۾HKk{j•r$Ő KP5>+ЊAo0Et# 矖?#ΝytQK0Gȸ8{2nlsy#Wx>>R7g IoTayçU͠TI49s>m VOz>,~kX[=vU܅C<8ÇԎ anH|cb3Dy -'i>|S S]\0"GˇO^+1Kѩ!w҇9ɆA h݃N~Mu;"cv^,|$֞ijMLfć`b{>{8zlOcPM D,zru{sznbա?qR {0Zaqa5ErQ z>By˅R%yM{68ٞRs^B dQ}n\M1}-3Gk+S2fXϑ8]!v2|huN˘tcYJwYn9?PQ㏇ GD:~LѲ3'j(3>>:۫6N7l2#_C 7R#(V!6a,\V*Ps|{)xI=zdI}js-T̬@UaG~qzHQo}gi~_4#-4z.]*B dg}ELL:1(`x}:^*Lu$LyF } ŎXY,#KUApp}aWתґ` n`rBEq3G=fJokzv.a?'`񲻔D:)C?FyUİM7K/dxDr3B(Y{N8]\4MR){TF`IutS+Fb T/^+\ܯzy4.ywakͻq踻yV{N@эcOc7-VЪ:7[uQ{%PgM0-שh|l?cLvJ:F|/.[2P\]6K{_i&Xz\h| ݫ SAh7 TEzb{^ .d$GɢσѷVv4E5ŘtX2^3%ݏ.j6Xje M/|׍@]V ,߼i)ZvD6q{\c !KߛhAu"F˘zܭ0,*>1v3ۋUMՒG^)X}&/ŐQr֭O0POszhnJ>0ު,/U3buh0ԦRC_g+&%vZ?1hf>Iz9=}h:9@jB?'y٩;N Cwi{PH~.oDGStv`*6_|bhⵍl]ܻtꬼ6B^\J]'{' > מ!mYB *"%Lw~Gw]FvS2 %1ka1󡰈|L'f1=3yzmZǘULo3¤q ,Xd Uu+5hh5\D$UM2|8<}S.>ױR[e52 /0ĶJ_UQHJ/T_nycP}6t#e=0gh)9QHBiEl/&$W>R pml.ğ{/91]pO0=2D"@EBb ؆S6gAXW8jB䛰\pvE=lᦁKJHsUJMd-}dS9{݄"e.V׫'_Ev_LA7~aسJ2}=~W6$~ ,NI7D]24`|n:?hӹ[:yohգ0CTF ZihO}r97Z,hߣOEufIEӗ|Q6ş~^ނgSejY,+`G gw_WZ0_BGߴ5湋KuQsJLE|f#.a>ơ,7ǬJj Y=Ŀ}8B΄hDjQh~fζ?^ǕgkuC%Y]ˈׇՏQk)O8NS 'GN鱏x[5Hi)+1kӚc£`c"hsunR:0H؂Ɨ{q 7gPY]Po(o >Ake>w]huɻ7P:JJ).:~G R}8(t -av7fa'pȽ1_O֓q'b0Co#̓¢ݘQZSM.Sˆv؆u^_I-SgL ~bEoRvͻ[Db&r$7NHt;yHĸ:Xw kB񷟲Pu,UɦDLx/%'<+/sDٕ- {cE}Ut SrIAnրugREt5֟?RV2j?-$cJn~aq\~I+-t\zDGWfo*!x/à-S2#Ct=iTu/-l**2oiJpcG'L"> :`$NY xWf'`컡*) x!֑sATOPt^, ;5V=HE}i{ūީ{#"~q3s8MSQ/(e8du+wYs-҈ cgTzru 'M㘆x+W0S>WGX%r_">(/(,FBZ5' ̱ђm+ͥuiR xsN?xBbEm>P7CHW9b$CvM=DXG֑LI)t$gYC/ @3gǧe*Q̍Eߘ6^<[osv|4[ X"LIXG|XO]䈏iEЖHPС!B/?18'S"/<ż̕'֓v QK޸ '=ƹ#DG{3or/ $7ډkG1w`>6nԗ#Y"[t:m\%&__H:FWnk;:qIW~T[Ď|hM#s9؃G0.8,S.r_p/|D )HSovaeL2 H߃WDBV=-D~9?15wˡ2QWGLLVYii*>A5.ӂFГAr@ΓƏ5s=gߎbNj_t k,D31,#̮L[k kBteq)^Bp}AL2Q5<4 X3EGm-r>un|&/c/ 0\H@N[[P;H?QC &F BO ׯ37rh9d'MVx飯=l)"6g%188p~&_ (rg&MDaHp${(ڔpV2+RIšg%ʫt5J|Wfk?.A)K<+|ǫv 6\EtFcDb9*\c Fg}c-:AXTeQ3Cj bȼ7_SL20?Ik2k$ Ž*'Fk-Q)">x21󿑜{n 潳>rG ^[v;UId1$^]??r E+Dכ(9#g[4o=T?Z%cER^ Jz* FS}8um!znc ؓO5X jս诜&b>~Žۯ01C0-nA?6짯aԝ-t7 p\,^ 1?HmH˃[")R]U\xUq~+K<{}ߌ#n%q喍TM Mk,lT.b4ǦMȺZzfD:%UiMzg(Ι a.0CFjK !hc# }04&4##`"^opG^+셌k0j],̡$:NN۾"]#׫"2Hk+"v7h@0M2cW7s0oUy%OJ U6]߅Z?YvrrW=Cu찼r7M3a>gb fBo/OMHw>/k2CΊ.ϰnHoxzDG)-E,0K lhUxt 7vCeĥ 澺3`,}] F`ӞCx=m&=q&lg-bUC:li]-һkv6]\wvDuzf]wRq˃0He|Õ?aBn0Y2|~/ih"$9TwO~)Wږwd'c6ƶ64YCfqI`4Z ?dx%[NzҰ) wsZ(,bbbvb\qt`0&&Ci[n-LBiD7o y}1ʤ_T~GΡxh \o=vB/ :4cQ$-B ß^ec|0tVmIHEj Yhccj b:O6?tz' oڋs!06'~WE/[ZJQ\ /񵓎}ϜƠ]}E?n{Ha퀳  +dti6t;К]s1}։JAbچP[kT_d)+31' aaaG׿pgXZ09U#C.}thەK7'V[ƀ/ɗXvNDGmRWL&ԑy}CJI6WȑXVJ^⿮ ܾYI+ be53ZD'M3+H'Mr ˻Yw/S!HR.RƋn٤b4 Od",@݊.)̐y^:sI&v豝b^OW/QI2UUL_t{Ǿҥ"x9X"J\H@:?#O=BGRq/AEG<~+^Xœ7Ec +{|ͯr_Sc#Ud 齔%Z*vS5 8_`"H$ (qDLJr*=zxe9&3;u{Ε<CZ:ߙeqOAATr~ $ve -SW(oE~\o6H\IZ_жgBa%( [1 N!x7{G!Vv bGBG1G n:wќbAV?Vrrl$fX.eJA C޼e)%FOU8؂ěmjK=Dɷ9f%-KkxY#}B7?w=D\^.CțYY4ɭvm@B@e'Iϛc+K&ϩsO=? 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moellermoeller### R code from vignette source 'qvalue.Rnw' ################################################### ### code chunk number 1: input ################################################### library(qvalue) data(hedenfalk) length(hedenfalk) ################################################### ### code chunk number 2: qvalue.Rnw:83-84 ################################################### hist(hedenfalk) ################################################### ### code chunk number 3: qvalue.Rnw:92-93 ################################################### qobj <- qvalue(hedenfalk) ################################################### ### code chunk number 4: qvalue.Rnw:96-97 ################################################### hist(qobj$qvalues) ################################################### ### code chunk number 5: qvalue.Rnw:105-106 ################################################### qsummary(qobj) ################################################### ### code chunk number 6: qvalue.Rnw:119-120 ################################################### qplot(qobj) ################################################### ### code chunk number 7: qvalue.Rnw:131-132 ################################################### qwrite(qobj) r-bioc-qvalue-1.34.0/inst/doc/qvalue.Rnw0000755000175000017510000001370212127130117017636 0ustar moellermoeller% \VignetteDepends{stats} % \VignetteIndexEntry{qvalue Tutorial} % \VignetteKeywords{Significance Analysis} % \VignettePackage{qvalue} \documentclass[11pt]{article} \usepackage{epsfig} \usepackage{latexsym} \usepackage{amsmath} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsxtra} \usepackage{graphicx,subfigure} \usepackage{vmargin} \newcommand{\Robject}[1]{{\texttt{#1}}} \newcommand{\Rfunction}[1]{{\texttt{#1}}} \newcommand{\Rpackage}[1]{{\texttt{#1}}} \newcommand{\Rclass}[1]{{\texttt{#1}}} \newcommand{\Rmethod}[1]{{\texttt{#1}}} \newcommand{\Rfunarg}[1]{{\texttt{#1}}} \parindent 0in \setpapersize{USletter} \setmarginsrb{1truein}{0.5truein}{1truein}{0.5truein}{16pt}{30pt}{0pt}{20truept} \setlength{\emergencystretch}{2em} \begin{document} \title{Bioconductor's qvalue package} \author{Alan Dabney and John Storey \\ Department of Biostatistics \\ University of Washington \\ email: \texttt{jstorey@u.washington.edu}} \maketitle \bibliographystyle{plain} \tableofcontents % library(tools) % Rnwfile <- file.path("c:/alan/biostat/storey/fdr/package/vignette", "qvalue.Rnw") % Sweave(Rnwfile) \section{Overview} The \Rpackage{qvalue} package contains functions for the computation and presentation of q-values for features from an experiment with multiple comparisons. A q-value is a measure of significance for a particular feature, analagous to a p-value. However, where the p-value assigns significance in terms of the false positive rate, the q-value assigns significance in terms of the false discovery rate. See \cite{storey:tibs:2003} for more detailed information.\\ This document provides a tutorial for using the \texttt{qvalue} package. The package consists of four functions (\Rfunction{qvalue} for computing q-values from p-values, \Rfunction{qplot} for visualizing the results with graphs, \Rfunction{qsummary} for visualizing the results with a table, and \Rfunction{qwrite} for writing the output to file) and a GUI (\Rfunction{qvalue.gui}). As with any R package, detailed information on functions, their arguments and value, can be obtained in the help files. For instance, to view the help file for the function \Rfunction{qvalue} within R, type \texttt{? qvalue}. \\ \section{Case study: the breast cancer dataset of Hedenfalk et al. (2001)} We demonstrate the functionality of this package using gene expression data from the breast cancer study of \cite{hedenfalk:etal:2001}. Comparison was made between two types of genetic mutation that are associated with an increased risk of breast cancer, BRCA1 and BRCA2. There were 7 and 8 cDNA arrays for BRCA1 and BRCA2, respectively. The example considered here is restricted to $3,170$ genes as described in \cite{storey:tibs:2003}. A 2-sample t-statistic was used to compare the two mutation types, gene by gene, and p-values were assigned by a permutation-based simulation of the null distribution. The original data and code for preprocessing can be found at \begin{center} \texttt{http://faculty.washington.edu/$\sim$jstorey/qvalue/results.html}. \end{center} The p-values from the BRCA1/BRCA2 analysis are included with the \Rpackage{qvalue} package as the dataset \texttt{hedenfalk}. To obtain the p-values, type \texttt{data(hedenfalk)}, and to view a description of the experiments and data, type \texttt{? hedenfalk}. We also check the length of the p-value vector and plot a histogram.\\ <>= library(qvalue) data(hedenfalk) length(hedenfalk) @ <>= hist(hedenfalk) @ \section{The \Rfunction{qvalue} function} The \Rfunction{qvalue} function computes q-values from the p-values of an experiment with multiple comparisons. We assign the output of the function call to the object \texttt{qobj} and plot a histogram of the q-values. <<>>= qobj <- qvalue(hedenfalk) @ <>= hist(qobj$qvalues) @ \section{The \Rfunction{qsummary} function} The \Rfunction{qsummary} function reports an estimate ($\pi_0$) of the proportion of genes for which the null hypothesis is true, and presents a table comparing p-values to q-values. <<>>= qsummary(qobj) @ \section{The \Rfunction{qplot} function} The \Rfunction{qplot} function produces four plots: \begin{itemize} \item A plot of $\pi_0$ versus the tuning parameter $\lambda$ (see \cite{storey:tibs:2003}). \item A plot comparing p-values to q-values. \item A plot of the number of significant genes by q-value. \item A plot of the number of expected false positives by the number of significant genes. \end{itemize} <>= qplot(qobj) @ \section{The \Rfunction{qwrite} function} The \Rfunction{qwrite} function writes the output of the function \texttt{qvalue} to a file. If all defaults were chosen in the call to \Rfunction{qvalue}, the output file contains $\pi_0$ in the first row and a $3,071 \times 2$ matrix of p- and q-values in the rest. Note that \Rfunction{qwrite} writes to the file ``my-qvalue-results.txt'' in the working directory by default. The file name and location can be specified with the \Rfunarg{filename} argument to \Rfunction{qwrite}. <<>>= qwrite(qobj) @ \section{The \Rfunction{qvalue.gui} GUI} The \Rfunction{qvalue.gui} function launches a GUI with which you can conduct all the tasks described above. The GUI is described in full detail in the accompanying manual. It is launched by typing \texttt{qvalue.gui()}. \bibliography{qvalue} \begin{figure}[ht] \begin{center} \includegraphics[width=5in,height=5in]{pHist} \end{center} \caption{Histogram of p-values.} \end{figure} \begin{figure}[ht] \begin{center} \includegraphics[width=5in,height=5in]{qHist} \end{center} \caption{Histogram of q-values.} \end{figure} \begin{figure}[ht] \begin{center} \includegraphics[width=5in,height=5in]{qPlots} \end{center} \caption{Miscellaneous plots.} \end{figure} \end{document} r-bioc-qvalue-1.34.0/inst/doc/qvalue.bib0000755000175000017510000000411612127130117017623 0ustar moellermoeller@string{jasa="Journal of the American Statistical Association"} @string{jrssa="Journal of the Royal Statistical Society, Series A"} @string{jrssb="Journal of the Royal Statistical Society, Series B"} @Article{storey:tibs:2003, Author = "Storey, J.D. and Tibshirani, R.", Title = "Statistical significance for genome-wide experiments", Journal = "Proceedings of the National Academy of Sciences", Year = 2003, Volume = 100, Pages = "9440-9445", } @Article{storey:etal:2004, Author = "Storey, J.D. and Taylor, J.E. and Siegmund, D.", Title = "Strong control, conservative point estimation, and simultaneous conservative consistency of false discovery rates: A unified approach", Journal = jrssb, Year = 2004, Volume = 66, Pages = "187-205", } @Article{storey:2002, Author = "Storey, J.D.", Title = "A direct approach to false discovery rates", Journal = jrssb, Year = 2002, Volume = 64, Pages = "479-498", } @Article{storey:2003, Author = "Storey, J.D.", Title = "The positive false discovery rate: A Bayesian interpretation and the q-value", Journal = "Annals of Statistics", Year = 2003, Volume = 31, Pages = "2013-2035", } @Article{benjamini:hochberg:1995, Author = "Benjamini, Y. and Hochberg, Y.", Title = "Controlling the false discovery rate: A practical and powerful approach to multiple testing", Journal = jrssb, Year = 1995, Volume = 85, Pages = "289-300", } @Article{ihaka:gentleman:1996, Author = "Ihaka, R. and Gentleman, R.", Title = "R: A language for data analysis and graphics", Journal = "Journal of Computational and Graphical Statistics", Year = 1996, Volume = 5, Pages = "299-314", } @Article{hedenfalk:etal:2001, Author = "Hedenfalk, I. and Duggan, D. and Chen, Y.D. and Radmacher, M. and Bittner, M. and Simon, R. and Meltzer, P. and Gusterson, B. and Esteller, M. and Kallioniemi, O.P. and Wilfond, B. and Borg, A. and Trent, J.", Title = "Gene expression profiles in hereditary breast cancer", Journal = "New Engl. Jour. Medicine", Year = 2001, Volume = 344, Pages = "539-548", }r-bioc-qvalue-1.34.0/inst/doc/qvalue.pdf0000644000175000017510000057111012127220315017640 0ustar moellermoeller%PDF-1.4 % 3 0 obj << /Length 2062 /Filter /FlateDecode >> stream xڭXGsFWpF rr# $h(@b/6^&Ĺxb w{68 N964IBAdiMWdՇ,=Z*8l֖͋-Χrhe n\(==*4W߲,K6!8UA(}Cl.a(2B)jS:m5g89wɤKɭZOr":٨Ɠ|G0qT'MUM#"|(VY$)D(Q0q*!2FG7$mwM 8ЂRVc rKv71g b3`  I3Ü]#d$XqȉC[`a2:i6?qMɏ*q$3h$,5}諅 ɻ!:moөs@g kmQtDȐ u]*0iނGvΎ7Ha a8&d/w5E)mwWr`yzd{ +~?6l(AVӨc7,Hă$NW2j/yt"cBgJovIQX@SV {:2 uoP'*tvͪW[aL%!#}~o(? 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(2001)} \usage{ data(hedenfalk) } \description{ The data come from the breast cancer cDNA microarray experiment of Hedenfalk et al. (2001). In the original experiment, comparison was made between 3,226 genes of two mutation types, BRCA1 (7 arrays) and BRCA2 (8 arrays). The data included here are p-values obtained from a two- sample t-test analysis on a subset of 3,170 genes, as described in Storey and Tibshirani (2003).} \value{ \item{hedenfalk}{Vector of 3,170 p-values of tests comparing BRCA1 to BRCA2.} } \references{ Hedenfalk I et al. (2001). Gene expression profiles in hereditary breast cancer. New Engl. Jour. Medicine, 344: 539-548. Storey JD and Tibshirani R. (2003). Statistical significance for genome-wide studies. Proceedings of the National Academy of Sciences, 100: 9440-9445.} \keyword{datasets} r-bioc-qvalue-1.34.0/man/qplot.rd0000755000175000017510000000612712127130116016372 0ustar moellermoeller\name{qplot} \alias{qplot} \alias{plot.qvalue} \title{Graphical display of qvalue objects} \description{ Graphical display of qvalue objects } \usage{ qplot(qobj, rng = c(0, 0.1), smooth.df = 3, smooth.log.pi0 = FALSE, \ldots) \method{plot}{qvalue}(x, \ldots) } \arguments{ \item{qobj, x}{Qvalue object.} \item{rng}{Range of q-values to consider. Optional.} \item{smooth.df}{Number of degrees-of-freedom to use when estimating \eqn{\pi_0}{pi_0} with a smoother. Optional.} \item{smooth.log.pi0}{If TRUE and \code{pi0.method} = "smoother", \eqn{\pi_0}{pi_0} will be estimated by applying a smoother to a scatterplot of \eqn{log} \eqn{\pi_0}{pi_0} estimates against the tuning parameter \eqn{\lambda}{lambda}. Optional.} \item{\ldots}{Any other arguments.} } \details{ The function qplot allows one to view several plots: \enumerate{ \item The estimated \eqn{\pi_0}{pi_0} versus the tuning parameter \eqn{\lambda}{lambda}. \item The q-values versus the p-values \item The number of significant tests versus each q-value cutoff \item The number of expected false positives versus the number of significant tests } This function makes fours plots. The first is a plot of the estimate of \eqn{\pi_0}{pi_0} versus its tuning parameter \eqn{\lambda}{lambda}. In most cases, as \eqn{\lambda}{lambda} gets larger, the bias of the estimate decreases, yet the variance increases. Various methods exist for balancing this bias-variance trade-off (Storey 2002, Storey & Tibshirani 2003, Storey, Taylor & Siegmund 2004). Comparing your estimate of \eqn{\pi_0}{pi_0} to this plot allows one to guage its quality. The remaining three plots show how many tests are significant, as well as how many false positives to expect for each q-value cut-off. A thorough discussion of these plots can be found in Storey & Tibshirani (2003). } \value{ Nothing of interest. } \references{ Storey JD. (2002) A direct approach to false discovery rates. Journal of the Royal Statistical Society, Series B, 64: 479-498. Storey JD and Tibshirani R. (2003) Statistical significance for genome-wide experiments. Proceedings of the National Academy of Sciences, 100: 9440-9445. Storey JD. (2003) The positive false discovery rate: A Bayesian interpretation and the q-value. Annals of Statistics, 31: 2013-2035. Storey JD, Taylor JE, and Siegmund D. (2004) Strong control, conservative point estimation, and simultaneous conservative consistency of false discovery rates: A unified approach. Journal of the Royal Statistical Society, Series B, 66: 187-205. QVALUE Manual \url{http://faculty.washington.edu/~jstorey/qvalue/manual.pdf} } \author{John D. Storey \email{jstorey@u.washington.edu}} \seealso{\code{\link{qvalue}}, \code{\link{qwrite}}, \code{\link{qsummary}}, \code{\link{qvalue.gui}}} \examples{ \dontrun{ p <- scan(pvalues.txt) qobj <- qvalue(p) qplot(qobj) qwrite(qobj, filename=myresults.txt) # view plots for q-values between 0 and 0.3: plot(qobj, rng=c(0.0, 0.3)) } } \keyword{misc} r-bioc-qvalue-1.34.0/man/qsummary.rd0000755000175000017510000000230112127130116017077 0ustar moellermoeller\name{qsummary} \alias{qsummary} \alias{summary.qvalue} \title{Display qvalue object} \description{ Display summary information for a qvalue object. } \usage{ qsummary(qobj, cuts = c(1e-04, 0.001, 0.01, 0.025, 0.05, 0.1, 1), digits = getOption("digits"), \ldots) \method{summary}{qvalue}(object, \ldots) } \arguments{ \item{qobj, object}{Qvalue object} \item{cuts}{Vector of significance value to use for table (optional)} \item{digits}{Significant digits to display (optional)} \item{\ldots}{Any other arguments} } \details{ \code{qsummary} shows the original call, estimated proportion of true null hypotheses, and a table comparing the number of significant calls for the raw p-values and for the calculated q-values using a set of cutoffs given by \code{cuts}. } \value{ Invisibly returns the original object. } \author{Alan Dabney \email{adabney@u.washington.edu} and Gregory R. Warnes \email{gregory\_r\_warnes@groton.pfizer.com}} \seealso{\code{\link{qvalue}}, \code{\link{qplot}}, \code{\link{qwrite}}, \code{\link{qvalue.gui}}} \examples{ \dontrun{ qobj <- qvalue(p) print(qobj) summary(qobj, cuts=c(0.01, 0.05)) } } \keyword{misc} r-bioc-qvalue-1.34.0/man/qvalue.gui.rd0000755000175000017510000000130112127130116017300 0ustar moellermoeller\name{qvalue.gui} \alias{qvalue.gui} \title{A graphical user interface for QValue} \description{ A graphical user interface for QValue } \usage{ qvalue.gui(dummy = NULL) } \arguments{ \item{dummy}{Dummy argument to facilitate documentation (no arguments required)} } \details{ This is a point-and-click version of \code{qvalue}. See the manual at \url{http://faculty.washington.edu/~jstorey/qvalue/manual.pdf} for documentation. } \value{ Nothing of interest. } \author{Alan R. Dabney \email{adabney@u.washington.edu}} \seealso{\code{\link{qvalue}}, \code{\link{qplot}}, \code{\link{qwrite}}, \code{\link{qsummary}}} \examples{ \dontrun{ qvalue.gui() } } \keyword{misc} r-bioc-qvalue-1.34.0/man/qvalue.rd0000755000175000017510000000721112127130116016523 0ustar moellermoeller\name{qvalue} \alias{qvalue} \title{Estimate the q-values for a given set of p-values} \description{ Estimate the q-values for a given set of p-values. The q-value of a test measures the proportion of false positives incurred (called the false discovery rate) when that particular test is called significant. } \usage{ qvalue(p=NULL, lambda=seq(0,0.90,0.05), pi0.method="smoother", fdr.level=NULL, robust=FALSE, gui=FALSE, smooth.df=3, smooth.log.pi0=FALSE) } \arguments{ \item{p}{A vector of p-values (only necessary input)} \item{lambda}{The value of the tuning parameter to estimate \eqn{\pi_0}{pi_0}. Must be in [0,1). Optional, see Storey (2002).} \item{pi0.method}{Either "smoother" or "bootstrap"; the method for automatically choosing tuning parameter in the estimation of \eqn{\pi_0}{pi_0}, the proportion of true null hypotheses} \item{fdr.level}{A level at which to control the FDR. Must be in (0,1]. Optional; if this is selected, a vector of TRUE and FALSE is returned that specifies whether each q-value is less than fdr.level or not.} \item{robust}{An indicator of whether it is desired to make the estimate more robust for small p-values and a direct finite sample estimate of pFDR. Optional.} \item{gui}{A flag to indicate to 'qvalue' that it should communicate with the gui. Should not be specified on command line. Optional.} \item{smooth.df}{Number of degrees-of-freedom to use when estimating \eqn{\pi_0}{pi_0} with a smoother. Optional.} \item{smooth.log.pi0}{If TRUE and \code{pi0.method} = "smoother", \eqn{\pi_0}{pi_0} will be estimated by applying a smoother to a scatterplot of \eqn{log} \eqn{\pi_0}{pi_0} estimates against the tuning parameter \eqn{\lambda}{lambda}. Optional.} } \details{ If no options are selected, then the method used to estimate \eqn{\pi_0}{pi_0} is the smoother method described in Storey and Tibshirani (2003). The bootstrap method is described in Storey, Taylor & Siegmund (2004). } \value{ A list containing: \item{call}{function call} \item{pi0}{an estimate of the proportion of null p-values} \item{qvalues}{a vector of the estimated q-values (the main quantity of interest)} \item{pvalues}{a vector of the original p-values} \item{significant}{if fdr.level is specified, and indicator of whether the q-value fell below fdr.level (taking all such q-values to be significant controls FDR at level fdr.level)} } \references{ Storey JD. (2002) A direct approach to false discovery rates. Journal of the Royal Statistical Society, Series B, 64: 479-498. Storey JD and Tibshirani R. (2003) Statistical significance for genome-wide experiments. Proceedings of the National Academy of Sciences, 100: 9440-9445. Storey JD. (2003) The positive false discovery rate: A Bayesian interpretation and the q-value. Annals of Statistics, 31: 2013-2035. Storey JD, Taylor JE, and Siegmund D. (2004) Strong control, conservative point estimation, and simultaneous conservative consistency of false discovery rates: A unified approach. Journal of the Royal Statistical Society, Series B, 66: 187-205. QVALUE Manual \url{http://faculty.washington.edu/~jstorey/qvalue/manual.pdf} } \author{John D. Storey \email{jstorey@u.washington.edu}} \seealso{\code{\link{qplot}}, \code{\link{qwrite}}, \code{\link{qsummary}}, \code{\link{qvalue.gui}}} \examples{ \dontrun{ p <- scan("pvalues.txt") qobj <- qvalue(p) qplot(qobj) qwrite(qobj, filename="myresults.txt") qobj <- qvalue(p, lambda=0.5, robust=TRUE) qobj <- qvalue(p, fdr.level=0.05, pi0.method="bootstrap") } } \keyword{misc} r-bioc-qvalue-1.34.0/man/qwrite.rd0000755000175000017510000000223012127130116016535 0ustar moellermoeller\name{qwrite} \alias{qwrite} \title{Write the results of the q-value object qobj to a file} \description{ Write the results of the q-value object qobj to a file. } \usage{ qwrite(qobj, filename = "my-qvalue-results.txt") } \arguments{ \item{qobj}{Qvalue object} \item{filename}{Output filename (optional)} } \details{ The output file lists the estimate of \eqn{\pi_0}{pi_0}, which is the proportion of true null hypotheses. It also lists each p-value and corresponding q-value, one per line. If an FDR significance level was specified in the call to \code{\link{qvalue}}, the significance level is printed below the estimate of \eqn{\pi_0}{pi_0}, and an indicator of significance is included as a third column for each p-value and q-value. } \value{ Nothing of interest. } \author{Alan Dabney \email{adabney@u.washington.edu} and John D. Storey \email{jstorey@u.washington.edu}} \seealso{\code{\link{qvalue}}, \code{\link{qplot}}, \code{\link{qsummary}}, \code{\link{qvalue.gui}}} \examples{ \dontrun{ p <- scan("pvalues.txt") qobj <- qvalue(p) qplot(qobj) qwrite(qobj, filename="myresults.txt") } } \keyword{misc}